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Hospice Basics, Hospice at Home
September 25, 2023

End-of-Life Timeline: Clinical Signs by Stage


Dying is a natural process accompanied by decrements in neurocognitive, cardiovascular, respiratory, and muscular function.

The dying process is highly variable and can last up to several weeks in some instances. Actively dying or imminent death represents the last week of life and has characteristic clinical signs detailed in the table below.

The expression of clinical end-of-life signs varies substantially between patients, but a greater number of clinical signs present within an individual increases the likelihood of death.

End-of-Life Stages Timeline

The identification of a patient transitioning to imminent death is important, so that clinicians can help educate patients and families about the natural dying process to inform decision-making as well as prepare the patient and family for death as much as feasible.

In addition, the care plan should be updated to reflect the change in the patient’s status, including any necessary clinical visits. A higher level of care may be needed on occasion for a period of crisis or uncontrolled symptoms not responding to initial treatments.

The table below demonstrates what to generally expect at each stage of death.

7+ Days Before Death

Clinical Signs Description Management Techniques
Peripheral edema Accumulation of fluid resulting in swelling, location is generally most dependent parts of the body such as the arms and legs Repositioning; Diuretics
Delirium Poor attention with acute onset and fluctuating course; severe confusion sometimes associated with hallucinations, abnormal drowsiness and/or restlessness, pacing, and agitation Evaluate for contributing causes; Reassurance, orientation, eye glasses/hearing aides; Discontinue anticholinergic medications; Antipsychotics
Dysphagia of solids Difficulty swallowing solids Education; Change food consistency
Decreased Speech Less able to communicate through words Education
Cool/Cold Extremities Skin of legs and then arms feels cold to the touch Education; Blankets

4-6 Days Before Death

Clinical Signs Description Management Techniques
Abnormal vitals High heart rate (>100) or respiratory rate (>20); Low systolic (<100) or diastolic(<60) blood pressure Educate; Discontinue blood pressure medications
Decreased level of consciousness Somnolence (sleepiness, drowsy, ready to fall asleep) and/or lethargy (drowsiness where the patient can’t be easily awakened) Educate
Dysphagia of liquids Difficulty swallowing liquids Educate; Keep mouth moist (wet sponge or oral swab, crushed ice, coating the lips with a lip balm)

2-3 Days Before Death

Clinical Signs Description Management Techniques
PPS 20% or less Bedbound, unable to do any work, total care, minimal intake/sips Educate
Peripheral cyanosis Bluish discoloration of extremities Educate
Decreased response to visual stimuli Decreased response to visual cues Educate
Drooping of the nasolabial fold Decrease in prominence/visibility of nasolabial fold Educate
Hyperextension of the neck Neck becomes hyperextended Educate; Opioids if pain present
Cheyne-Stokes breathing Alternating periods of apnea and hyperpnea with a crescendo-decrescendo pattern Educate; Opioids if dyspnea present
Nonreactive pupils Flash light into pupils to see if they react Educate
Decreased response to verbal stimuli Decreased response to verbal cues Educate

Less Than 2 Days Before Death

Clinical Signs Description Management Techniques
Death rattle Gurgling sound produced on inspiration and/or expiration related to airway secretions Educate; Repositioning; Anticholinergics if patient suffering
Apnea Prolonged pauses between each breath Educate; Opioids if dyspnea present
Respiration with mandibular movement Depression of jaw with inspiration Educate
Decreased urine output Measured volume of urine over a 12-hour period, <100 mL Educate
Pulselessness of radial artery Inability to palpate radial pulse Educate
Inability to close eyelids Eyelids do not close Educate; Wet washcloth if eyes dry/irritated
Grunting of vocal cords Sound produced predominantly on expiration, related to vibrations of vocal cords Educate; Opioids if pain present
Fever Temperature > 100 Cool wash cloth on their forehead and removing blankets; Fan; Acetaminophen

Clinical signs are based upon study in cancer patients but are generalizable to other causes of death (e.g. heart disease, advanced lung disease, sepsis, and dementia). The list is not exhaustive but includes some of the more common end-of-life symptoms.

Link Between Clinical Signs of Dying and Impending Death

A direct relationship exists between the number of clinical signs of dying and death:

  • Persons with two clinical signs of dying had a 40% chance of dying
  • Persons with eight clinical signs of dying had more than an 80% chance of dying

Therefore, the more clinical signs of death that are present necessitates a care plan update including necessary discipline visits.

The natural dying process results in clinical signs of dying where likelihood of death increases with the number of present end-of-life signs.

How Long Does the Active Stage of Dying Last? 

The active stage of dying generally only lasts for about 3 days. The active stage is preceded by an approximately 3-week period of the pre-active dying stage. Though the active stage can be different for everyone, common symptoms include unresponsiveness and a significant drop in blood pressure.

What Are the Emotional Signs of Death?

There are many forewarning signs that death is near besides clinical indicators and symptoms. Analyzing emotional signs can also shed light on a patient’s end-of-life status. Some of these signs include:

  • A prolonged state of excessive fatigue, sleep, perhaps being comatose-like
  • Confusion and/or disorientation; Hearing or seeing people and events not visible and not present to you
  • Social withdrawal and detachment
  • The desire to conduct a life review or settle something unresolved
  • The desire to focus on funeral planning  

Hospice Team Involvement During Stages of Dying

When clinical signs of dying emerge, the hospice interdisciplinary care team initiates a care plan update that includes:

  • Revisions to necessary interdisciplinary visits
  • Education on the dying process
  • Adjustments / additions of necessary medications
  • Assurance that appropriate HME is in place to assist your patient and their family

The hospice team provides support in a variety of ways, specific to each team member's discipline.

Nurse, nurse practitioner, and/or physician:

  • May discuss the discontinuation of non-beneficial or burdensome treatments
  • Ensure symptom medications and necessary equipment are available
  • Educate family on use of medications to manage symptoms and/or pain, and describe physiological changes associated with the dying process

Social worker and chaplain:

  • Help patients and families explore their feelings and relationships
  • Participate in life review, including the search for meaning and contributions
  • Conduct life closure, including forgiving and facing regrets, being able to say goodbye, and coming to terms with the acceptance of ongoing losses and death

Hospice aides:

  • Recognize the clinical signs of dying and communicate them to the other team members, as well as support the patient and family through the dying process.

How to Help Families Cope After a Loved One Has Died

After a patient dies, family members need time to process their feelings. They should not be subjected to additional stress with the logistics of legal forms or removal of the body.

Be empathetic

Medical professionals and care teams should keep in mind that the time, setting, and specific events surrounding a loved one’s death shape lasting memories for their family members—solemn moments that deserve to be respected and honored.

  • Give family members private time alone with their loved one after a death to say their goodbyes and share memories
  • Answer family members’ questions factually, calmly, and with empathy
  • Explain clearly and compassionately what will happen in the next several hours or days

Honor rituals

Honor families’ needs for specific rituals at the time of or shortly after death, such as private family time with the body, bathing of the body, recitation of prayers, or dressing of their loved one in special clothing or garments.

  • Make sure the immediate environment—whether the patient’s home, hospital room, nursing home/care facility room, inpatient hospice room, etc.—is as uncluttered, clean, and orderly as possible, with no offensive odors

Encourage a healthy grieving process

Remind family members and caregivers that each person’s grief is unique and will ebb and flow over the following day, weeks, months, and years. If the patient was on hospice care, Medicare-certified hospices provide up to a year of grief and loss counseling for their family following the patient’s death.

  • Invite family members and friends to stay in touch and rely on each other as they move through their grief
  • Hui D, dos Santos R, Chisholm G. et al. Bedside Clinical Signs Associated With Impending Death in Patients With Advanced Cancer: Preliminary Findings of a Prospective, Longitudinal Cohort Study. Cancer 2015;121:960-967.
  • Hui D, dos Santos R, Chisolm G, et al. Clinical Signs in Cancer Patients. The Oncologist 2014;19:681–687

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